Advances in research on small molecule regulators targeting HBV cccDNA generation and transcription
10.16438/j.0513-4870.2023-0094
- VernacularTitle:靶向HBV cccDNA生成和转录的小分子调控剂研究进展
- Author:
Xiang-rui XU
;
Yu JIN
;
Shu-jing XU
;
Shuo WANG
;
Yong HE
;
Xin-yong LIU
;
Peng ZHAN
- Publication Type:Research Article
- Keywords:
hepatitis B virus;
covalently closed circular DNA;
small molecule;
medicinal chemistry;
rug design
- From:
Acta Pharmaceutica Sinica
2023;58(10):2979-2994
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus (HBV) represents a significant global public health challenge. Despite the availability of several approved drugs for hepatitis B treatment, the persistence of covalently closed circular DNA (cccDNA) renders HBV eradication elusive, thereby leading to disease relapse after drug withdrawal. This paper reviews the regulatory mechanisms of cccDNA formation, transcription and replication, and summarizes the research progress of related small molecule regulators from the perspective of medicinal chemistry.
