Research progress of bacterial biofilm eradication agents based on modifications of natural products
10.16438/j.0513-4870.2023-0164
- VernacularTitle:基于天然产物改造的细菌生物膜清除剂研究进展
- Author:
Mao-cheng LI
1
,
2
;
Yu-she YANG
1
,
2
;
Dan ZHANG
3
Author Information
1. University of Chinese Academy of Sciences, Beijing 100049, China
2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
3. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
- Publication Type:Research Article
- Keywords:
bacterial biofilm;
biofilm eradication agent;
natural product;
quaternary ammonium cation;
halogenated phenazine
- From:
Acta Pharmaceutica Sinica
2023;58(9):2623-2631
- CountryChina
- Language:Chinese
-
Abstract:
Bacterial biofilm widely exists in all kinds of bacteria, and is related to about 80 percent of bacterial infections. It is one of the main reasons for bacterial tolerance and resistance to existing antibiotics. Therefore, there is unmet clinical need for new anti-biofilm drugs. At present, there are three kinds of anti-biofilm agents under research, including biofilm inhibitors, biofilm dispersal agents and biofilm eradication agents. Among them, the biofilm eradication agent is unique, which can not only kill bacteria in biofilm but also eliminate biofilm as a monotherapy. Based on modifications of natural products with antibacterial activity, a variety of compounds with biofilm eradicating activities have been obtained, such as, acyldepsipeptides, pyrrolomycins, halogenated phenazines and halogenated 8-hydroxyquinolines. In this review, we summarize several major biofilm eradication agents above according to their structures and mechanisms.
