Single cell RNA sequencing technology applicated for drug discovery
10.16438/j.0513-4870.2023-0123
- VernacularTitle:单细胞转录组测序技术在药物研究中的应用
- Author:
Mao-lin WANG
;
Hong-jun YANG
- Publication Type:Research Article
- Keywords:
single cell RNA sequencing;
rug discovery;
heterogeneity;
target discovery;
adverse reaction;
vaccine development
- From:
Acta Pharmaceutica Sinica
2023;58(9):2551-2559
- CountryChina
- Language:Chinese
-
Abstract:
Single cell RNA sequencing (scRNA-seq) is an advanced technology to study the transcriptome information at the single cell level. The application of this technology can attribute to analyze the heterogeneous map of cells in the process of disease development, and precisely identify the specific cell subsets that are responsive to pharmacological therapy. Currently, scRNA-seq technology has been widely applied in the field of drug research, including studies on therapeutic targets, drug-induced adverse reactions, drug resistance and vaccine. This work reviews the application of scRNA-seq technology in drug discovery, which offers a scientific basis for personalized and accurate medication therapy.
