Study on release and antioxidant activity of quercetin after loaded by hot alkali hydrolysis modified UiO-66 material
10.16438/j.0513-4870.2023-0101
- VernacularTitle:热碱解改性UiO-66材料对槲皮素的装载、释放及抗氧化作用研究
- Author:
Rui-miao CHANG
1
,
2
,
3
;
Yan-yang ZHANG
4
;
An-juan KANG
1
;
Guang-bin ZHANG
1
;
Yan-ping YU
1
;
Jun-zhao REN
1
;
An-jia CHEN
1
;
Yong LI
3
,
5
Author Information
1. School of Pharmacy, Shanxi Medical University, Taiyuan 030001, China
2. Shanxi Bethune Hospital (Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Third Hospital of Shanxi Medical University, Taiyuan 030032, China
3. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
4. Shanxi Liye Pharmaceutical Co., Ltd., Taiyuan 030021, China
5. Shanxi Bethune Hospital (Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital), Third Hospital of Shanxi Medical University, Taiyuan 030032, China
- Publication Type:Research Article
- Keywords:
quercetin;
UiO-66;
thermal alkaline hydrolysis;
adsorption performance;
antioxidant activity;
italic>in-vitro release
- From:
Acta Pharmaceutica Sinica
2023;58(9):2802-2810
- CountryChina
- Language:Chinese
-
Abstract:
UiO-66 (University of Oslo 66) is a kind of promising material that can improve the release and bioavailability of poorly water-soluble bioactive compounds of traditional Chinese medicine. However, the loading of quercetin in raw UiO-66 was not ideal. In this study, UiO-66-BH (UiO-66-blend-heating) was obtained by heating UiO-66 and KOH solution following blended them. UiO-66-BH maintained the outline of octahedral structure of UiO-66 but with obvious rough and uneven pores on the surface. UiO-66-BH had good adsorption of quercetin with saturation adsorption was 138.92 mg·g-1, the adsorption process belonged to single molecular layer adsorption and was controlled by chemisorption. UiO-66-BH can control the release of quercetin in simulated gastrointestinal fluid, and the drug concentration was significantly higher than that of free quercetin after long-term release (36% vs 9%). Compared with quercetin, the ABTS (2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) ammonium salt) radical scavenging activity of UiO-66-BH@quercetin drug delivery system decreased, while the DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity remained almost unchanged. The drug delivery system showed a strong antioxidant effect similar to quercetin. The findings indicated that UiO-66-BH could control release of quercetin and was expected to be used as a drug carrier material for some insoluble active components of traditional Chinese medicine such as quercetin.
