Research progress of SARS-CoV-2 main protease inhibitors
10.16438/j.0513-4870.2022-1364
- VernacularTitle:SARS-CoV-2主蛋白酶抑制剂的研究进展
- Author:
Mian-ling YANG
;
Yu-sen CHENG
;
Le-tian SONG
;
Bing YE
;
Sheng-hua GAO
;
Xin-yong LIU
;
Peng ZHAN
- Publication Type:Research Article
- Keywords:
COVID-19;
SARS-CoV-2;
main protease;
main protease inhibitor;
rug design
- From:
Acta Pharmaceutica Sinica
2023;58(9):2581-2600
- CountryChina
- Language:Chinese
-
Abstract:
As a common protease with high similarity among coronavirus species, the main protease (Mpro) of SARS-CoV-2 is responsible for the catalytic hydrolysis of viral precursor proteins into functional proteins, which is essential for coronavirus replication and is one of the ideal targets for the development of broad-spectrum antiviral drugs. This paper reviews the main protease inhibitors of SARS-CoV-2, including their molecular structures, potencies and drug-like profiles, binding modes and structure-activity relationships, etc.
