Establishment and Application of in vitro and in vivo Model of Disseminated Tumor Cells with Dormancy
10.3971/j.issn.1000-8578.2023.23.0585
- VernacularTitle:具有休眠特征的播散肿瘤细胞体内外研究模型的建立及应用
- Author:
Zujun QUE
1
;
Jiajun LIU
;
Jianhui TIAN
Author Information
1. Institute of Oncology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China
- Publication Type:Research Article
- Keywords:
Lung cancer metastasis;
Tumor dormancy;
Disseminated tumor cells;
Circulating tumor cells;
Research model
- From:
Cancer Research on Prevention and Treatment
2023;50(11):1127-1132
- CountryChina
- Language:Chinese
-
Abstract:
Postoperative asymptomatic patients with early cancer (lung cancer) have dormant disseminated tumor cells (DTCs) in their metastatic target organs, and the proliferation of these DTCs is the key link leading to clinical metastasis. The development of therapeutic agents to maintain DTCs dormant or eradicate dormant DTCs will prevent tumor metastasis and break through the bottleneck of improving the overall efficacy of treating malignant tumors. This paper reviews the methods of establishing in vitro and in vivo research models of DTCs with dormant characteristics to promote the understanding of dormant DTCs and improve the research and development efficiency of anti-tumor metastasis drugs.
