Current research status of traditional Chinese medicine in the prevention and treatment of hepatocellular carcinoma by regulating the JAK/STAT signaling pathway
10.3969/j.issn.1001-5256.2023.11.030
- VernacularTitle:中药调控Janus激酶/信号转导和转录激活因子（JAK/STAT）信号通路防治肝细胞癌的研究现状
- Author:
Xing YANG
1
;
Shudi LI
1
;
Jiangkai LIU
2
;
Zhen WANG
3
;
Suling LI
4
Author Information
1. The First Clinical Hospital of Henan University of Chinese Medicine， Zhengzhou 450046， China
2. Department of Hepatology and Spleen-Stomach， The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450000， China
3. Department of Scientific Research， The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450000， China
4. Chinese Medical Hall， The First Affiliated Hospital of Henan University of Chinese Medicine， Zhengzhou 450000， China
- Publication Type:Review
- Keywords:
Carcinoma， Hepatocellular;
Drugs， Chinese Herbal;
Signal Transduction
- From:
Journal of Clinical Hepatology
2023;39(11):2718-2729
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma （HCC） is one of the common malignant tumors of the digestive tract and seriously threatens the life of patients due to a high incidence rate， a high degree of malignancy， strong invasion and metastasis， and poor prognosis. At present， the main methods for the prevention and treatment of HCC include drugs， surgery， and interventional treatment， but all of these methods have certain adverse reactions and side effects. As an important intracellular signal transduction pathway in the human body， the JAK/STAT signaling pathway mainly exerts an anti-HCC effect by regulating cell invasion， metastasis， proliferation， growth， apoptosis， autophagy， angiogenesis， inflammation/immune response， iron metabolism， and drug resistance. Therefore， targeting the JAK/STAT signaling pathway plays an important role in the prevention and treatment of the development and progression of HCC. Traditional Chinese medicine has attracted wide attention due to its advantages of multiple targets， pathways， components， and levels in the treatment of HCC， and many cell or animal experiments on traditional Chinese medicine in the treatment of HCC have shown that the JAK/STAT signaling pathway is an important target for the prevention and treatment of HCC， with the effects of improving liver function， reducing HCC recurrence， and improving immunity. Based on this， this article analyzes the mechanism of action of the JAK/STAT signaling pathway in HCC， as well as the intervention effect of traditional Chinese medicine monomers， traditional Chinese medicine extracts， and traditional Chinese medicine compounds on the JAK/STAT signaling pathway， in order to provide theoretical basis and reference for the prevention and treatment of HCC and the research and development of new traditional Chinese medicine drugs.
