Gut-liver axis： Intestinal microbial homeostasis and hepatocellular carcinoma
10.3969/j.issn.1001-5256.2023.11.029
- VernacularTitle:肠-肝轴：肠道微生物稳态与肝细胞癌
- Author:
Quan ZHOU
1
;
Chunlin CAI
2
;
Jinqiang LI
1
Author Information
1. Department of Infectious Diseases， The First Hospital of Changsha， Changsha 410000， China）
2. Department of Hospital Infection Management， The First Hospital of Changsha， Changsha 410000， China
- Publication Type:Review
- Keywords:
Carcinoma， Hepatocellular;
Gastrointestinal Microbiome;
Bile Acids and Salts
- From:
Journal of Clinical Hepatology
2023;39(11):2710-2717
- CountryChina
- Language:Chinese
-
Abstract:
Intestinal microbiota plays an important role in maintaining liver metabolic homeostasis and affects the development and progression of hepatocellular carcinoma by participating in bile acid metabolism. Gut-liver axis plays an important role in the pathogenesis of liver diseases， and it might be one of the effective methods to prevent the progression of hepatocellular carcinoma by correcting intestinal ecological imbalance to restore normal bile acid level. This article summarizes the mechanism of bile acid receptor affecting hepatocellular carcinoma and the latest therapeutic targets， in order to provide a reference for the early prevention and treatment of hepatocellular carcinoma.
