The mechanism of the severe exacerbation and chronicity of hepatitis E virus infection
10.3969/j.issn.1001-5256.2023.11.003
- VernacularTitle:戊型肝炎病毒感染重症化和慢性化的机制
- Author:
Yuxin CHEN
1
;
Yijin WANG
1
Author Information
1. Medical School of Southern University of Science and Technology， Shenzhen， Guangdong 518055， China
- Publication Type:Journal Article
- Keywords:
Hepatitis E virus;
Hepatitis E;
Autoimmunity
- From:
Journal of Clinical Hepatology
2023;39(11):2530-2537
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis E virus （HEV） infection is the most common cause of acute viral hepatitis worldwide， and over the past ten years， studies have shown that HEV can not only cause acute self-limiting hepatitis， but also lead to severe and chronic infection. Pregnant women or patients with underlying liver disease may progress to liver failure after HEV infection， resulting in a relatively high mortality rate， and patients receiving solid organ transplantation may progress to chronic hepatitis after HFV infection. This article introduces the diagnosis， clinical features， transmission， prevention， and treatment of severe and chronic HEV infection， discusses the features of immune response， inflammatory response， and the virus itself during the severe exacerbation and chronicity of HEV infection， and summarizes the mechanism in promoting the progression of HEV. Nevertheless， there are still large gaps between current studies and clinical application， and there is still a lack of effective diagnosis and treatment regimens for severe and chronic HEV infection. It is necessary for clinical researchers to conduct research on the pathogenesis of hepatitis E and systematic cohort studies and improve the level of clinical nursing， thereby achieving the goal of preventing hepatitis E and improving the prognosis of patients with hepatitis E.
