Clinical profile and outcomes in acute viral encephalitis
- Author:
Albert Roland Alcaraz
1
;
Martha Lu-Bolanos
1
;
Ma. Liza Antoinette M. Gonzales
1
Author Information
- Publication Type:Journal Article
- Keywords: Acute viral encephalitis; Dengue encephalitis
- MeSH: Acute Febrile Encephalopathy; Encephalitis, Japanese
- From: Pediatric Infectious Disease Society of the Philippines Journal 2016;17(2):37-46
- CountryPhilippines
- Language:English
-
Abstract:
Objective:This study aimed to determine the clinical profile and outcome of pediatric patients with acute viral encephalitis syndrome admitted at a single tertiary government hospital.
Methods:All pediatric patients admitted at the Philippine General Hospital from January 2011 to December 2014 and discharged with a final diagnosis of acute viral encephalitis were included. After demographic data, clinical manifestations, and laboratory findings were collected, the outcome was determined using the Modified Rankin Scale for children. The data were summarized using descriptive statistics. The median test was used to compare the outcomes while the chi-square test was used to analyze the comparison between study groups.
Results:Sixty-four patients diagnosed with acute viral encephalitis syndrome were included in the study. The highest number of cases was reported in ages 1- 4 years (32.81%) and among the male population (68.75%). The most common symptoms were seizure (46.87%), abnormal behavior (21.88%), and altered sensorium (20.31%). Forty-four patients had CSF viral studies done, and among them, the 11 (25%) were positive for Japanese encephalitis. The modified Rankin scale showed that 41 (64.08 %) subjects showed good outcomes, while 23 (35.23%) exhibited poor outcomes. There was no significant difference in the modified Rankin scale for Japanese encephalitis compared to the other etiologic agents of acute viral encephalitis (p value= 0.717).
Conclusion:In patients with acute viral encephalitis, the most common symptoms were seizures, abnormal behavior, and altered sensorium. Majority of the subjects did not show any significant symptoms and disability. No difference was seen in the clinical outcome of patients infected with Japanese encephalitis compared to other etiologic agents, but these results need to be verified by larger studies.< - Full text:jo51_ja05.pdf
