Beta cell function, insulin resistance and low grade systemic inflammation in Myanmar adults with different categories of glucose tolerance
- Author:
Mo-Mo-Than
1
;
May Thazin
2
;
Tint Swe Latt
3
Author Information
- Publication Type:Journal Article
- Keywords: Beta cell function
- MeSH: Diabetes Mellitus; Insulin Resistance; Glucose Intolerance; Myanmar
- From: Journal of the ASEAN Federation of Endocrine Societies 2013;28(1):1-6
- CountryPhilippines
- Language:English
-
Abstract:
Objective:The aim of the study was to evaluate the beta cell function, insulin sensitivity and low grade systemic inflammation in different categories of glucose tolerance in Myanmar.
Methodology:A cross-sectional study was conducted on 202 Myanmar subjects of both sexes, aged between 45-65 years old. Fasting blood glucose, insulin, C-peptide and hs-CRP levels were measured. A 75g oral glucose tolerance test was performed. Insulin resistance and beta cell function were assessed by homeostasis-model-assessment (HOMA).
Results:The subjects were categorized as normal glucose tolerance (NGT), impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and diabetes mellitus (DM) according to WHO-2006 criteria. Fasting serum insulin, C-peptide and hs-CRP levels and insulin resistance index (HOMA-IR) progressively increased from NGT through prediabetes (IFG, IGT) to DM (p<0.01). Beta-cell function did not change significantly in any other group as compared to normal group.
Conclusion:After multivariate analysis, increases in fasting C-peptide, hs-CRP and HOMA-IR index were significantly associated with diabetes. It was also found that insulin resistance was a predominant feature in deterioration of the glucose tolerance in Myanmar subjects. - Full text:54-Article Text-267-1-10-20140524.pdf
