Effect of oral calcium supplementation on lipid profile and atherogenic index of plasma
- Author:
Mya Thanda Sein
1
;
Tint Swe Latt
2
;
Ohnmar
1
Author Information
- Publication Type:Journal Article
- Keywords: Calcium supplementation; Lipid profile; Atherogenic index of plasma
- From: Journal of the ASEAN Federation of Endocrine Societies 2014;29(2):135-140
- CountryPhilippines
- Language:English
-
Abstract:
Objective:To assess the effect of oral calcium supplementation on lipid profile and atherogenic index of plasma (AIP).
Methodology:This study was undertaken in 28 centrally obese male subjects [age 26.4 (6.5) years], BMI 31.6 (4.7) kg/m2, WC 99.4 (6.4) cm. All participants received six tablets of CaCO3 (250 mg of elemental calcium/ capsule, for a total of 1500 md/day) for 8 weeks. Serum lipid profile including triglyceride, total cholesterol, HDL-C, LDL- C was measured at baseline and after intervention. AIP was calculated by using formula = log (TG/HDL-C).
Results:Oral calcium supplementation achieved a 22% (36 mg/dL, p<0.001) reduction in Triglyceride from baseline [163.4 (37.9) mg/dL] and 19.2% ( 5.8 mg/dL, p<0.001) increase in HDL-C from baseline [30.4 (7.4) mg/dL)]. There were no significant treatment effects on total cholesterol [217.1 (41.21) mg/dL vs 196.3 (46.2) mg/dL] and LDL-C [155.4 (45.1) mg/dL vs 136.3 (45.1) mg/dL]. Significant reduction in serum total cholesterol and LDL-C level was only found in dyslipidemic centrally obese subjects. AIP decreased significantly by 51% with calcium carbonate treatment [median and interquartile range; 0.35 (0.29-0.44) vs 0.17 (0.04-0.44), p<0.01].
Conclusion:Eight-week calcium supplementation at 1500 mg/day led to a significant change in lipid levels and AIP. - Full text:128-Article Text-1677-1-10-20141129.pdf
