Effect of cholecalciferol on GLUT4 expression in adipocyte of diabetic rats

Author: Dewi Ratna Sari ¹ ; Rimbun ¹ ; Tri Hartini Yuliawati ¹ ; Joni Susanto ¹ ; Ari Gunawan ¹ ; Harjanto JM ²
Author Information

1. Department of Anatomy and Histology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia
2. Department of Physiology, Faculty of Medicine, Universitas Airlangga, Surabaya, East Java, Indonesia
Publication Type:Journal Article
Keywords: GLUT4; Diabetes
MeSH: Cholecalciferol; Adipocytes
From: Journal of the ASEAN Federation of Endocrine Societies 2015;30(2):190-193
CountryPhilippines
Language:English
Abstract: This research was conducted to examine the effect of cholecalciferol on fasting blood glucose (FBG), adipocyte diameter and glucose transporter (GLUT) 4 expression in adipocytes of diabetic rats. Nineteen male Wistar strain diabetic rats were divided into 4 groups (K, X1, X2 and X3). Cholecalciferol was administered in the amount of 6.25 μg/kg in X1, 12.5 μg/kg in X2 and 25 μg/kg in X3 per orem, once daily for 14 days. Group K received the placebo. There were no significant differences in FBG (p=0.199) and adipocyte diameter (p=0.218) between groups but there were significant differences in the expression of GLUT4 between control and treatment groups. Thus, cholecalciferol can increase GLUT4 expression in adipocyte without altering FBG and adipocyte diameter of diabetic rats.
Full text:197-Article Text-2887-1-10-20151204.pdf