Hepatitis C: A Review on Current and Emerging Genotyping Assays
https://doi.org/10.47836/mjmhs.19.5.41
- Author:
Nur Amalin Zahirah Mohd Amin
1
;
Tuan Nur Akmalina Mat Jusoh
1
;
Ahmad Adebayo Irekeola
2
;
Rafidah Hanim Shueb
1
Author Information
1. Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia
2. Microbiology Unit, Department of Biological Sciences, College of Natural and Applied Sciences, Summit University Offa, Offa Kwara State, Nigeria
- Publication Type:Review
- Keywords:
Hepatitis, Hepatitis C virus (HCV), Genotype, Genotyping, Molecular diagnostic
- From:Malaysian Journal of Medicine and Health Sciences
2023;19(No.5):359-370
- CountryMalaysia
- Language:English
-
Abstract:
Hepatitis C is a global public health concern that infects millions of people worldwide. The continual discovery of
new genotypes and subtypes of hepatitis C virus (HCV) is an indication of a persistent molecular evolution of the
virus. This remains a concern in the efforts towards hepatitis C elimination, as effective management of the disease
is, in part, dependent on the HCV genotype responsible for the infection. Accurate HCV screening and quantification
using rapid but highly sensitive and reliable methods are crucial for the diagnosis and subsequent management of
HCV-related diseases. Thus, this article discusses HCV and the common methods employed for HCV detection and
genotyping. While nucleotide sequencing and phylogenetic analysis of core/E1 and NS5B region are regarded as
the gold standard and the most recommended method used for HCV genotyping, electrochemical sensors are being
explored for their rapidity.
- Full text:11.2023my1643.pdf
