Effect of Plant Extracts on Protein Changes During Adipogenesis: A Scoping Review
https://doi.org/10.47836/mjmhs.19.5.39
- Author:
Nur Dayana Hassan Cheong
1
;
Emida Mohamed
1
;
Norhisham Haron
1
;
Siti Nazrina Camalxaman
1
Author Information
1. Centre of Medical Laboratory Technology, Faculty of Health Sciences, Universiti Teknologi MARA, Selangor Branch, Puncak Alam Campus, 42300 Puncak Alam, Selangor, Malaysia
- Publication Type:Review
- Keywords:
Adipogenesis, Antiobesity, Plant extract, Protein changes, Scoping review
- From:Malaysian Journal of Medicine and Health Sciences
2023;19(No.5):331-344
- CountryMalaysia
- Language:English
-
Abstract:
Plant extracts are gaining popularity among researchers as alternatives from natural sources for the treatment of
obesity and inhibition of adipogenic differentiation is one of the mechanisms targeted by these extracts. The main
focus of this scoping review is to specifically identify the phytochemicals within the extracts, and the protein changes that occurred during adipogenesis when subjected to the various plant extracts as well as to identify the gaps in
the previous studies. A systematic search was conducted using predetermined keywords on three online databases
(SCOPUS, PubMed, and ScienceDirect). Overall, a total of 988 articles were retrieved, leaving only 43 articles after
applying the exclusion criteria. The selected studies looked at the effects of phytochemicals found in plant extracts
on the alterations in adipogenesis-related proteins that results in adipocyte differentiation inhibition mainly in 3T3-L1
cells and mice. Despite plant extracts being the basis of numerous hyperlipidemic treatments, not much is focused
on the changes in adipogenic proteins such as PPARs, CEBPs, or SREBPs. Thus, in this review, we discuss how the
plant extracts aid in obesity prevention, and possible further research required to fully utilize the natural sources for
the betterment of public health.
- Full text:11.2023my1641.pdf
