Application of Proteomics in Alzheimer’s Disease: A Mini Review
https://doi.org/10.47836/mjmhs.19.5.38
- Author:
Pariveena Sukumaran
1
;
Ainun Aida Bahardin
1
;
Luqmanul Hakim Abdul Razak
1
;
Mohd Harizal Senik
1
,
2
Author Information
1. Department of Neurosciences, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia&
2. Brain and Behaviour Cluster, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
- Publication Type:Review
- Keywords:
Alzheimer’s disease, Proteomics, Mass Spectrometry
- From:Malaysian Journal of Medicine and Health Sciences
2023;19(No.5):317-330
- CountryMalaysia
- Language:English
-
Abstract:
Alzheimer’s disease (AD) is classified as one of neurodegenerative disease caused by neuronal death. It is characterized as memory impairment, including the inability to produce new memories. Since AD has low treatment effectiveness, proteomics research opens possibilities for advancement. Proteomics is the study of proteomes produced
by the disease-bearing host to identify and understand diseases. In this case, to investigate the use of protein as a
reliable molecular entity and their involvement in AD. Therefore, this review focused on three main applications of
proteomics; the potential use of proteomics as a diagnostic tool for AD, the use of proteomics to assess the treatment
progression of AD and the advancement in AD research. The review discussed three research areas utilizing the proteomics approach: ageing, behavioural, and demographic research of AD populations. Proteomic approaches have
also been shown to be effective to discover the biomarkers for infectious diseases, cancers, heart diseases, and neurological disorders. Although much work remained to be done, the proteomics approach is an interesting method to be
carried out in detecting AD at an earlier stage and will be very useful for AD treatment and management in the future.
- Full text:11.2023my1640.pdf
