Cost-effectiveness analysis of ferric carboxymaltose for treating iron deficiency anemia in adult Chinese patients
- VernacularTitle:羧基麦芽糖铁治疗中国缺铁性贫血成人患者的成本-效果分析
- Author:
Wentao SUN
1
,
2
;
Lingxiang ZHUANG
3
;
Aixia MA
1
Author Information
1. School of International Pharmaceutical Business，China Pharmaceutical University，Nanjing 211198，China
2. Vifor Fresenius Kabi （Beijing） Pharmaceutical Consulting Co. Ltd.，Beijing 100028，China
3. Dept. of Epidemiology and Global Health，Umeå University，Umeå 90130，Sweden
- Publication Type:Journal Article
- Keywords:
Ferric carboxymaltose injection;
iron deficiency anemia;
cost-effectiveness analysis;
partitioned survival model
- From:
China Pharmacy
2023;34(22):2750-2755
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To evaluate the cost-effectiveness of Ferric carboxymaltose injection in the treatment of iron deficiency anemia in adult Chinese patients. METHODS From the perspective of China’s health system， the partitioned survival model was constructed to simulate the treatment process and outcome of patients with iron deficiency anemia using ferric carboxymaltose and iron sucrose based on the ferric carboxymaltose phase Ⅲ clinical trial in China （NCT03591406）. The study period was 1 year. Total costs and quality-adjusted life years （QALYs） were calculated for both treatment regimens， and incremental cost-effectiveness ratios were calculated. Scenario analysis was performed with different assumptions for efficacy parameters between 9th week and the end of 1 year， and from the perspective of China’s health system and the entire society. The sensitivity analysis was also performed. RESULTS In the basic analysis， compared with iron sucrose， incremental effectiveness of ferric carboxymaltose therapy was 0.007 QALYs， with an additional savings of 1 038 yuan per patient. Ferric carboxymaltose therapy was more effective and less costly， presenting an absolute advantage. The results of the scenario analysis and single-factor sensitivity analysis were consistent with the basic analysis. Probability sensitivity analysis showed that when the willingness-to-pay threshold was 1， 2， 3 times gross domestic product per capita in 2022， the probability of ferric carboxymaltose with a cost- effectiveness advantage was 88.2%，94.5% and 97.6%，respectively. CONCLUSIONS For Chinese adults with iron deficiency anemia， ferric carboxymaltose is a cost-effective treatment for iron deficiency anemia， compared with iron sucrose.
