Epidemiological analysis on the susceptibility of CXCR3 gene polymorphism to COPD in the elderly population in Liangjiang New Area of Chongqing
10.3969/j.issn.1006-2483.2023.06.036
- VernacularTitle:CXCR3基因多态性在重庆两江新区老年人群中慢性肺阻塞性肺疾病易感性的流行病学分析
- Author:
Feng JIN
1
,
2
;
Tianjia ZHU
1
,
2
;
Huan YE
1
,
2
Author Information
1. Medical Laboratory Department of Chongqing Liangjiang New Area People'
2. s Hospital , Chongqing 401120 , China
- Publication Type:Journal Article
- Keywords:
CXC chemokine receptor 3;
Gene polymorphism;
Chronic obstructive pulmonary disease
- From:
Journal of Public Health and Preventive Medicine
2023;34(6):152-156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore and analyze the epidemiology of susceptibility to chronic obstructive pulmonary disease (COPD) among the elderly population in Liangjiang New Area of Chongqing based on CXC chemokine receptor 3 (CXCR3) gene polymorphism. Methods From January 2020 to September 2022, the Medical Laboratory Department of Chongqing Liangjiang New Area People's Hospital selected COPD patients and received treatment. Among the 276 patients who met the criteria were included in the study and included in the observation group. Among the 512 patients with healthy pulmonary function in the same period were included in the control group. The data of the two groups of patients were analyzed, and the genotypes were detected by SBaPhotoshot technology to analyze the relationship between gene polymorphism and the susceptibility and clinical characteristics of COPD. Results There was no significant difference between the two groups in age, sex, BMI and blood eosinophil granulocyte levels, which was comparable (P>0.05). There were significant differences in smoking history, pulmonary function index , MMP-9 and TIMP-1 levels (P<0.05). Compared with the control group, the homozygous TT of rs2280964 locus in the observation group had a higher risk of COPD than that of CC (P<0.05), but there was no significant difference in gene distribution between the two groups at rs34334103 locus (P>0.05). In the observation group, the MMP-9 level of rs2280964 locus was significantly different (P=0.003), while the TIMP-1 level was not significantly different (P=0.187); There was no significant difference in MMP-9 and TIMP-1 levels among the three genes at rs34334103 locus (all P>0.05). The level of MMP-9 in homozygous TT patients with rs2280964 locus was significantly higher than that in homozygous CC patients (P=0.024). There were differences in FEV1/FVC of patients with CXCR3 rs34,334,103 gene distribution (P=0.008), among which there were significant differences in CC+CT and TT recessive models (P<0.01), and the level of FEV1/FVC of TT type was the lowest. There was no significant correlation between other SNP loci and clinical symptoms of COPD (all P>0.05). Conclusion CXCR3 gene polymorphism is significantly associated with the susceptibility to COPD, and also with the serum levels of MMP-9 and FEV1/FVC, which can be used as a new target for clinical research and treatment.
