Evaluation on the blocking effect of hepatitis B vaccine on mother-to-infant transmission in 302 cases and analysis of influencing factors
10.3969/j.issn.1006-2483.2023.06.032
- VernacularTitle:302例乙型肝炎疫苗母婴阻断效果评价及影响因素分析
- Author:
Juan LIU
1
,
2
;
Long HU
3
;
Lihua WANG
4
;
Lixian WANG
2
,
5
;
Yanfei CHEN
5
;
Yan TANG
5
;
Jiaojiao ZOU
2
,
6
;
Long HU
3
;
Long HU
3
Author Information
1. Tongcheng Center for Disease Control and Prevention , Xianning , Hubei 437000, China
2. Hubei Provincial Field Epidemiology Training Program ,Wuhan , Hubei 430079 , China
3. Hubei Provincial Center for Disease Control and Prevention ,Wuhan , Hubei 430079 , China
4. Xiangyang Center for Disease Control and Prevention , Xiangyang , Hubei 441022 , China
5. XiaoNan Center for Disease Control and Prevention , Xiaogan , Hubei 432100 , China
6. Wuhan Center for Disease Control and Prevention ,Wuhan , Hubei 430015 , China
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Vaccine;
Mother-to-child blockade
- From:
Journal of Public Health and Preventive Medicine
2023;34(6):136-139
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of the current immunization strategy for hepatitis B virus (Hepatitis B) in blocking mother-to-infant transmission in Hubei Province, and to explore the mechanism and possible influencing factors of failure of mother-to-infant blockade. Methods A multi-stage random sampling method was used to select 2 counties or districts in Hubei Province. Through maternity hospital health handbook, neonatal health record or hospital medical record system, hepatitis B virus (HBV) surface antigen (HBsAg)-positive pregnant women in 2012-2018 years were included to retrospectively investigate their delivery status and the HBV infection status of their children. Results Among the 302 newborns, 32 were positive for HBsAg, and the success rate of blockade of mother-to-infant transmission of hepatitis B was 89.45%. Further analysis showed that 68.21% (206 / 302) of newborns were delivered in township hospitals, 66.23% (200 / 302) were delivered by caesarean section and 41.72% (126 / 302) were breastfed, while 16.89% (51/302) were positive for hepatitis B virus e antigen (HBeAg), and 41.06% (124/302) were positive for anti-HBe. The vaccination rate of hepatitis B immunoglobulin (HBIG) during pregnancy was 3.31% (10/302), and the newborn HBIG vaccination rate was 94.37% (285/302). There were 84.11% (254/302) of pregnant women taking protective measures in daily life. Logistic regression analysis showed that township hospitals (OR=2.82, P<0.05), HBeAg positivity during pregnancy (OR=8.68, P<0.05), and HBIG vaccination during pregnancy (OR=12.62 , P<0.05) were risk factors for failure of mother-to-infant blockade, while anti-HBe positivity during pregnancy (OR=0.22, P<0.05), vaccination of newborns with HBIG (OR=0.20, P<0.05), and protective measures taken in daily life (OR=0.28, P<0.05) were protective factors for mother-to-infant interruption. Conclusion Deliveries in township hospitals and HBeAg-positivity during pregnancy are more likely to fail in blocking of mother-to-infant transmission of hepatitis B. HBIG vaccination during pregnancy does not reduce the risk of blockade failure. Neonatal HBIG vaccination, anti-HBe positivity during pregnancy, and protective measures in daily life can reduce the risk of blockade failure of mother-to-infant transmission of hepatitis B.
