Study on the relationship between the risk of Parkinson's disease complicated with cerebral infarction and the serum level of tyrosine hydroxylase and its potential influencing factors
10.3969/j.issn.1006-2483.2023.06.031
- VernacularTitle:帕金森合并脑梗死风险与酪氨酸羟化酶血清表达水平的关联及潜在影响因素
- Author:
Sha KE
1
;
Bo LIAO
2
;
Zhaohui YANG
3
;
Xiaoming WANG
1
Author Information
1. Department of Neurology , Affiliated Hospital of North Sichuan Medical College, Nanchong , Sichuan 637002, China
2. Department of Urology , Affiliated Hospital of North Sichuan Medical College , Nanchong , Sichuan 637002 ,China
3. Department of Burn and Plastic, Affiliated Hospital of North Sichuan Medical College , Nanchong , Sichuan 637002 , China
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Cerebral infarction;
Tyrosine hydroxylase;
Inflammatory factors;
Oxidative stress
- From:
Journal of Public Health and Preventive Medicine
2023;34(6):132-135
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum levels of tyrosine hydroxylase (TH) and the risk of cerebral infarction in Parkinson's patients. Methods A total of 129 patients with confirmed Parkinson's disease who were hospitalized in our hospital were selected, among the 58 patients had Parkinson's disease complicated with cerebral infarction (complicated with cerebral infarction group), and the remaining 71 patients had Parkinson's disease alone (control group). Blood TH levels and other potential related information were collected retrospectively at the time of diagnosis. Comparative analysis of data was performed using SPSS software. Results Comparing the serum TH expression levels in patients with Parkinson's disease and patients with cerebral infarction at admission , the serum TH level in patients with cerebral infarction was lower. Results also showed that the levels of CRP, IL-6, MDA, and Hcy were higher in patients with cerebral infarction, while PON-1 level was lower. In addition, patients with cerebral infarction had lower motor ability (higher UPDRS Ⅲ score). Further regression analysis was carried out with the occurrence of Parkinson's disease complicated with cerebral infarction as the dependent variable and the potential influencing factors as the independent variable. The results indicated that factors such as low expression of TH, high expression of inflammatory factors, and high expression of oxidative stress factors were positively correlated with the risk of complications of the two diseases. Conclusion The low expression of TH, inflammatory state and high oxidative stress state are the potential risk factors for Parkinson's disease complicated with cerebral infarction, which deserves clinical attention.
