Research progress on the relationship between Helicobacter pylori infection and the risk of coronary heart disease
10.3969/j.issn.1006-2483.2023.06.029
- VernacularTitle:幽门螺杆菌感染与冠心病发病风险的研究进展
- Author:
Fuxia LAN
1
;
Ying XYU
1
;
Xin WEI
1
Author Information
1. Department of Cardiology , West China Hospital ,Sichuan University , Chengdu , Sichuan 610041 , China
- Publication Type:Journal Article
- Keywords:
Coronary heart disease;
Helicobacter pylori;
Disease risk
- From:
Journal of Public Health and Preventive Medicine
2023;34(6):122-126
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori (Hp) can be colonized in human gastric mucosa for a long time and is related to various gastrointestinal diseases. At the same time, it may also participate in the occurrence of nervous system, blood system, endocrine and cardiovascular diseases. Coronary heart disease (CHD) is a common clinical cardiovascular system disease, which is characterized by the formation of coronary atherosclerotic plaques and myocardial ischemia damage. In serious cases, it may lead to myocardial infarction and heart failure, with a high risk of death and disability. Hp infection can play an important role in the occurrence and development of CHD through inflammation and immune response, endothelial dysfunction, hyperhomocysteinemia, dyslipidemia, metabolic syndrome, abnormal glucose tolerance, oxidative stress, and cytotoxic factors. In-depth research on the relationship between Hp infection and CHD is not only beneficial to improve clinical treatment regimen for Hp, but also helps to reduce the risk of Hp infection-related CHD, which provides reference for clinical treatment of the disease.
