Epidemiological characteristics and risk factors of nontuberculous Mycobacterium infection in elderly patients with ramus in Huai'an Area
10.3969/j.issn.1006-2483.2023.06.026
- VernacularTitle:淮安地区老年支扩患者发生非结核分枝杆菌感染的流行病学特征及危险因素分析
- Author:
Yunyun ZHOU
1
,
2
,
3
,
4
;
Guangxing GENG
2
,
3
,
5
,
6
;
Jing XYU
1
,
2
,
3
,
4
;
Xinlin SUN
1
,
2
,
3
,
4
Author Information
1. Department of Tuberculosis , Huai'
2. an Fourth People'
3. s Hospital , Huai'
4. an , Jiangsu 223001 , China
5. Department of Anesthesiology , Huai'
6. an , Jiangsu 223001 , China
- Publication Type:Journal Article
- Keywords:
Bronchiectasis;
Non-tuberculous mycobacterium;
Epidemiological characteristics
- From:
Journal of Public Health and Preventive Medicine
2023;34(6):108-111
- CountryChina
- Language:Chinese
-
Abstract:
Objective The epidemiological characteristics and risk factors of infection of non-tuberculous mycobacterial (NTM) by elderly bronchiectasis patients in Huai 'an area were analyzed, and the theoretical basis for prevention of NTM infection by elderly bronchiectasis patients in Huai 'an area was provided. Methods Among the 371 elderly patients with bronchiectasis admitted to our hospital from January 2020 to June 2022 were selected and divided into control group and NTM group according to whether they had NTM or not. The NTM strains were isolated and identified. Clinical data of patients were collected from the medical record system. Independent risk factors of NTM infection in elderly patients with ramus were analyzed by univariate analysis and logistic regression, including gender, age, previous smoking status, number of ramus, pulmonary cavities, hypoproteinemia, and CD4+T cell level. Results A total of 108 cases NTM infection (29.11%) among the 371 patients with branch enlargement. There was no statistical significance in cough, phlegm, hemoptysis and fever between the two groups (P>0.05). The proportion of chest tightness and shortness in NTM group was significantly higher than that in control group (P<0.05). Six mycobacterium species were isolated from 108 patients with NTM infection, including 57 intracellular, 22 abscess, 14 avium, 7 Kansas, 5 terrapin and 3 flavus. There were significant differences in age, sex, smoking history, place of residence, number of brandished lobes, hypoproteinemia, pulmonary cavities, and number of CD4+T lymphocytes between the two groups (P<0.05). Multivariate logistic regression analysis showed that smoking history >20 years (OR=1.692), number of branchial dilated lobe ≥5 (OR=2.671) and thin-walled cavity (OR=2.458) were independent risk factors for NTM infection in elderly patients with branchial dilated lobe (P<0.05). Conclusion Elderly patients with bronchiectasis in Huai 'an area have a high risk of NTM infection, which are mainly Mycobacterium intracellular and mycobacterium abscess. The main risk factors are the number of bronchiectasis lung ≥5, smoking history >20 years, and thin-walled cavity. Patients should actively quit smoking, improve the body immunity, and prevent NTM infection in patients with bronchiectasis.
