Changes of FeNO, CRP and PCT levels in patients with bronchial asthma complicated with sleep apnea syndrome in Shanghai
10.3969/j.issn.1006-2483.2023.06.023
- VernacularTitle:上海地区支气管哮喘合并睡眠呼吸暂停综合征患者FeNO、CRP和PCT水平变化及危险因素分析
- Author:
Yufan XIE
1
,
2
;
Haitao SHEN
1
,
2
Author Information
1. Department of Laboratory , Seventh People'
2. s Hospital of Shanghai University of Traditional Chinese Medicine , Shanghai 200137, China
- Publication Type:Journal Article
- Keywords:
Bronchial asthma;
Sleep apnea syndrome;
FeNO, CRP and PCT levels
- From:
Journal of Public Health and Preventive Medicine
2023;34(6):95-98
- CountryChina
- Language:Chinese
-
Abstract:
Objective The changes and risk factors of FeNO, CRP and PCT in patients with bronchial asthma complicated with sleep apnea syndrome (SAS) in Shanghai area were analyzed to provide theoretical basis for the prevention and treatment of SAS in patients with bronchial asthma. Methods A total of 436 patients with bronchial asthma admitted to our hospital from January 2019 to June 2022 were selected and divided into control group and experimental group according to whether SAS occurred during hospitalization. The experimental group was divided into three subgroups according to the apnea hypopnea index (AHI) values: mild group (AHI>15 times /h or <30 times /h), moderate group (AHI>15 times /h or <30 times /h) and severe group (AHI≥30 times /h).The serum FeNO, CRP and PCT levels were compared between the two groups. Clinical data of patients were collected from the medical record system. Univariate analysis and logistic regression were used to analyze the factors affecting the occurrence of SAS in patients with bronchial asthma. Results Among the 436 patients with bronchial asthma,158(36.24%)had SAS,including 76 mild,54 moderate and 28 severe;The levels of serum FeNO,CRP,PCT and AHI in the experimental group were significantly higher than those in the control group(P<0.05).Serum FeNO,CRP,PCT and AHI levels in severe group were significantly higher than those in mild group(t=5.830,7.597,7.885,40.684,P<0.05).Serum FeNO,CRP,PCT and AHI levels in severe group were significantly higher than those in moderate group(t=2.895,3.455,3.001,18.841,P<0.05).The levels of serum FeNO,CRP,PCT and AHI in the moderate group were significantly higher than those in the mild group(t=2.924,4.157,6.201,23.640,P<0.05).BMI>28 kg/m2(OR=5.629),allergic rhinitis(OR=6.166)and neck circumference>40 cm(OR=5.265)were independent risk factors for SAS in patients with bronchial asthma(P<0.05);Pearson correlation analysis showed that AHI was positively correlated with serum FeNO,CRP and PCT levels in patients with bronchial asthma and SAS(r=0.471,0.436,0.502,P<0.05). Conclusions Patients with old bronchial asthma in Shanghai area have a higher risk of SAS, and the severity of the disease is positively correlated with the levels of FeNO, CRP and PCT. In particular, obese patients with allergic rhinitis should be given early intervention to reduce the risk of SAS.
