Protective effect of Shenmajing formula on ischemic brain injury in mice
10.12206/j.issn.2097-2024.202208066
- VernacularTitle:参麻颈复方对脑缺血损伤小鼠的脑保护作用及其机制研究
- Author:
Jingxue LIU
1
,
2
;
Ruihua HE
3
;
Xia TAO
2
;
Jin HUANG
3
Author Information
1. Department of Pharmacy, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
2. Department of Pharmacy, Second Affiliated Hospital of Naval Medical University, Shanghai, 200003, China.
3. Department of Pharmacy, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China.
- Keywords:
Shenmajing formula;
cerebral ischemic injury;
endothelial progenitor cells;
neurological function
- From:
Journal of Pharmaceutical Practice
2023;41(11):666-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the protective effect of Shenmajing formula on brain tissue of mice with cerebral ischemic injury and explore the possible mechanism. Methods Thirty SPF-grade C57 BL/6 male mice were randomly divided into model control group, Shenmajing group and nimodipine group, and the animal models of cerebral ischemic injury in mice were prepared by electrocoagulation. The protein expression level in endothelial progenitor cells were detected by Western blot. Results Compared with the model control group, the infarct volume of mice in the Shenmajing group was significantly reduced, and the migration, adhesion and tubule formation ability of endothelial progenitor cells were significantly improved, and the expression level of BDNF protein in endothelial progenitor cells was significantly increased. Conclusion The protective effect of Shenmajing granules on brain tissue of mice with cerebral ischemic injury could be closely related to the regulation of BDNF expression in endothelial progenitor cells and improvement of endothelial progenitor cell function of bone marrow origin.
