Progress on factors affecting gastrointestinal function and drug protection in high altitude hypoxia environment
10.12206/j.issn.2097-2024.202111018
- VernacularTitle:高原低氧环境影响胃肠道功能的因素及药物保护作用研究进展
- Author:
Junfei CHENG
1
,
2
;
Anpeng ZHAO
3
;
Yilan ZHAO
1
,
2
;
Zihan WANG
3
;
Wenbin LI
3
;
Rong WANG
1
,
2
Author Information
1. Department of Pharmacy, the 940th Hospital of Joint Logistics Support force of CPLA, Lanzhou 730050, China
2. School of pharmacy, Lanzhou university, Lanzhou 730000, China.
3. Department of Pharmacy, the 940th Hospital of Joint Logistics Support force of CPLA, Lanzhou 730050, China.
- Keywords:
high altitude hypoxia;
gastrointestinal motility;
gastrointestinal mucosa;
intestinal flora
- From:
Journal of Pharmaceutical Practice
2023;41(11):648-653
- CountryChina
- Language:Chinese
-
Abstract:
Due to factors such as low pressure, low oxygen and cold in the plateau environment, people who enter the plateau rapidly are susceptible to digestive system diseases, such as upper abdominal pain, loss of appetite, nausea and vomiting and other gastrointestinal dysfunction, which seriously affect the health and work ability of people who enter the plateau rapidly. The gastrointestinal dysfunction caused by the rapid advance to the plateau is mainly reflected in three aspects: gastrointestinal motility dysfunction, impaired mucosal barrier function, and intestinal flora imbalance. At present, the pathogenesis of gastrointestinal dysfunction is still not very clear, and there are fewer drugs for targeted prevention and treatment. Gastrointestinal hormones, oxygen free radicals, inflammatory factors, intestinal flora and other factors, as well as the protective effects of related drugs were reviewed in this paper to provide treatment options and theoretical basis for the prevention and treatment of the gastrointestinal emergency response caused by entering the plateau.
