Association between Serum Fibroblast Growth Factor 21 and Coronary Artery Disease in Patients with Type 2 Diabetes.
10.3346/jkms.2015.30.5.586
- Author:
Won Jin KIM
1
;
Sang Soo KIM
;
Han Cheol LEE
;
Sang Heon SONG
;
Min Jung BAE
;
Yang Seon YI
;
Yun Kyung JEON
;
Bo Hyun KIM
;
Yong Ki KIM
;
In Joo KIM
Author Information
1. Department of Internal Medicine, Pusan National University Hospital, Busan, Korea. injkim@pusan.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Fibroblast Growth Factor-21;
Diabetes Mellitus, Type 2;
Coronary Artery Disease
- MeSH:
Adolescent;
Adult;
Aged;
Aged, 80 and over;
Coronary Angiography;
Coronary Artery Disease/complications/*diagnosis/pathology;
Diabetes Mellitus, Type 2/complications/*diagnosis;
Female;
Fibroblast Growth Factors/*blood;
Humans;
Male;
Middle Aged;
Regression Analysis;
Severity of Illness Index;
Young Adult
- From:Journal of Korean Medical Science
2015;30(5):586-590
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of this study was to evaluate the association of plasma fibroblast growth factor (FGF)-21 with angiographically significant coronary artery disease (CAD) in patients with type 2 diabetes mellitus. Serum FGF-21 was measured in 120 patients undergoing coronary angiography. Patients were divided into 4 groups based on the presence/absence of type 2 diabetes mellitus and of significant CAD. The atherosclerotic burden was obtained by two angiographic scores: Gensini score (GS) and Extent score (ES). FGF-21 levels were higher in type 2 diabetes mellitus than in non-diabetic patients (P = 0.014). FGF-21 levels were significantly correlated with GS (r = 0.358, P < 0.001) and ES (r = 0.324, P < 0.001) in univariate analysis with all patients. After adjusting for several confounding factors, both GS and ES were associated with FGF-21 in all patients (r = 0.271, P = 0.014; r = 0.217, P = 0.041, respectively). However, FGF-21 lost significant correlation with both GS and ES with type 2 diabetes mellitus in the final model. The patients with type 2 diabetes mellitus and CAD feature had elevated FGF-21 levels. Despite of a limited role in diabetic patients, FGF-21 levels are independently associated with angiographic severity and extent of CAD.
