Current status of animal models of cataract classified by etiology
10.3980/j.issn.1672-5123.2023.12.10
- VernacularTitle:按病因分类的白内障动物模型制作现状
- Author:
Shi-Yi LI
1
;
Qian-Fang FU
1
;
Ju HUANG
1
;
Pei-Pei ZHANG
1
;
Kang WANG
1
;
Ying-Bin XIE
1
Author Information
1. Department of Ophthalmology, Binzhou Medical University Hospital, Binzhou 256603, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
cataract;
animal model;
etiologic classification
- From:
International Eye Science
2023;23(12):1988-1993
- CountryChina
- Language:Chinese
-
Abstract:
Cataract is one of the major causes of vision loss and even blindness in patients, and surgery is the only effective method to treat it. The pathogenesis and precaution of cataract remain hot issues in ophthalmological research. With the maturation of biotechnology in recent years, modeling methods and species of experimental animals have become more diverse, which are still the mainstay of cataract mechanism research. However, the ideal animal model of cataract has yet to be constructed due to the complexity of human cataract etiology. Herein, the modeling principles, in vivo or in vitro modeling methods, characteristics, and existing problems of animal models of cataract are summarized according to etiology, providing the theoretical foundation for the construction of a comprehensive animal model that more closely resembles the human cataract.
