Functional Magnetic Resonance Imaging of Motor Cortex Activation in Schizophrenia.
10.3346/jkms.2015.30.5.625
- Author:
Hyo Jong LEE
1
;
Adrian PREDA
;
Judith M FORD
;
Daniel H MATHALON
;
David B KEATOR
;
Theo G M VAN ERP
;
Jessica A TURNER
;
Steven G POTKIN
Author Information
1. Division of Computer Science and Engineering, CAIIT, Chonbuk National University, Jeonju, Korea. hlee@chonbuk.ac.kr
- Publication Type:Original Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
- Keywords:
Motor Cortex;
Schizophrenia;
Motor Dysfunction;
Functional MRI;
Laterality Quotient;
Power Analysis
- MeSH:
Adult;
Aged;
Brain Mapping;
Case-Control Studies;
Female;
Healthy Volunteers;
Humans;
*Magnetic Resonance Imaging;
Male;
Middle Aged;
Motor Cortex/anatomy & histology/*radiography;
Schizophrenia/*diagnosis;
Visual Cortex/anatomy & histology/radiography;
Young Adult
- From:Journal of Korean Medical Science
2015;30(5):625-631
- CountryRepublic of Korea
- Language:English
-
Abstract:
Previous fMRI studies of sensorimotor activation in schizophrenia have found in some cases hypoactivity, no difference, or hyperactivity when comparing patients with controls; similar disagreement exists in studies of motor laterality. In this multi-site fMRI study of a sensorimotor task in individuals with chronic schizophrenia and matched healthy controls, subjects responded with a right-handed finger press to an irregularly flashing visual checker board. The analysis includes eighty-five subjects with schizophrenia diagnosed according to the DSM-IV criteria and eighty-six healthy volunteer subjects. Voxel-wise statistical parametric maps were generated for each subject and analyzed for group differences; the percent Blood Oxygenation Level Dependent (BOLD) signal changes were also calculated over predefined anatomical regions of the primary sensory, motor, and visual cortex. Both healthy controls and subjects with schizophrenia showed strongly lateralized activation in the precentral gyrus, inferior frontal gyrus, and inferior parietal lobule, and strong activations in the visual cortex. There were no significant differences between subjects with schizophrenia and controls in this multi-site fMRI study. Furthermore, there was no significant difference in laterality found between healthy controls and schizophrenic subjects. This study can serve as a baseline measurement of schizophrenic dysfunction in other cognitive processes.
