A Experimental Study on Pharmacokinetics of Cefazolinum in Rats with Paraplegia
- VernacularTitle:截瘫与正常鼠体内头孢唑啉药物动力学的实验研究
- Author:
Qing LIU
;
Xueyuan JIN
;
Yuezhu MA
;
Li LIU
- Publication Type:Journal Article
- Keywords:
pharmacokinetics, paraplegia
- From:
Chinese Journal of Rehabilitation Theory and Practice
1995;1995(1):28-31
- CountryChina
- Language:Chinese
-
Abstract:
Wistar male rats were divided into two grorps, The experimental group was madethe paraplegia model. BOth groups were received cefazolinum 250 mg through single-dosed intra-venous injection. The concentration was measured by HPLC. The result implied that a).the concentra-tion of cefazolinum in paraplegic group was higher than that in control group either the distributingphase or the eliminating phase(p<0. 001);b). the pharmacokinetic parameters showed that the apparent vlumeof distribution:(v1,v2)was decreased and the elimination. half-life(t1/2β)was more length-y in paraplegia group. So that the drug concentration increased. The conclusion is that the dosege on thepatients with paraplegia should be clinically monitored,especilly following hepatic and renal disfunctionand with the drugs with narrowed safety range.
