Advances in the protective mechanism and clinical implications of autophagy in liver failure
10.3969/j.issn.1001-5256.2023.10.030
- VernacularTitle:自噬对肝衰竭的保护作用机制与临床价值
- Author:
Yangyang HU
1
;
Xing ZHANG
1
;
Yue LUO
1
;
Yadong WANG
1
;
Caiyan ZHAO
1
Author Information
1. Department of Infectious Diseases， Xiangjiang Branch of The Third Hospital of Hebei Medical University， Shijiazhuang 050051， China
- Publication Type:Review
- Keywords:
Liver Failure;
Autophagy;
Molecular Targeted Therapy
- From:
Journal of Clinical Hepatology
2023;39(10):2485-2490
- CountryChina
- Language:Chinese
-
Abstract:
Liver failure is a serious clinical syndrome of liver disease with critical condition and high mortality， and besides liver transplantation， there is still a lack of satisfactory radical treatment methods. The pathogenesis of liver failure is complex and remains unclear， involving a variety of factors that affect the balance of hepatocyte necrosis and regeneration. This article summarizes autophagy as the key pathway for maintaining cell homeostasis and points out that autophagy plays an important protective role in the pathogenesis of liver failure by regulating NLRP3 inflammasome activation， reducing oxidative stress， and inhibiting cell apoptosis. Meanwhile， it is believed that the molecular signaling pathways targeting autophagy， such as exosomes and peroxisome proliferator－activated receptor α， participate in antagonizing the development and progression of liver failure and will become important ideas and directions for molecular targeted therapies for liver failure.
