Research advances in the association between metabolic associated fatty liver and type 2 diabetes mellitus and the mechanism of comorbidity
10.3969/j.issn.1001-5256.2023.10.025
- VernacularTitle:代谢相关脂肪性肝病与2型糖尿病的关系及共病机制研究进展
- Author:
Zhaobin CHEN
1
;
Liyuan HUANG
1
;
Bingyuan WANG
2
;
Junping SHI
3
;
Jing ZHANG
4
Author Information
1. School of Clinical Medicine， Jining Medical University， Jining， Shandong 272000， China
2. Department of Elderly Gastroenterology， The First Affiliated Hospital of China Medical University， Shenyang 110000， China
3. Department of Liver Diseases， The Affiliated Hospital of Hangzhou Normal University， Hangzhou 310000， China
4. Department of Gastroenterology， Affiliated Hospital of Jining Medical University， Jining， Shandong 272000， China
- Publication Type:Review
- Keywords:
Diabetes Mellitus， Type 2;
Metabolic Associated Fatty Liver Disease;
Insulin Resistance;
Inflammation;
Cytokines;
Cellular Senescence
- From:
Journal of Clinical Hepatology
2023;39(10):2454-2459
- CountryChina
- Language:Chinese
-
Abstract:
There are gradual increases in the incidence rates of metabolic associated fatty liver disease （MAFLD） and type 2 diabetes mellitus （T2DM）， with close relationship and mutual interaction between the two diseases， but the specific mechanism is still unclear. Studies have shown that T2DM and MAFLD may cause aggravation of each other through insulin resistance， inflammation， some hepatocyte factors， and cellular senescence and protect each other through some hepatocyte factors. Further research on the association between T2DM and MAFLD and the mechanism of comorbidity is of great significance for the clinical prevention and treatment of the two diseases.
