Research advances in hepatitis E virus infection in pregnancy
10.3969/j.issn.1001-5256.2023.10.024
- VernacularTitle:妊娠合并戊型肝炎研究进展
- Author:
Manhua ZHONG
1
;
Jingyue WANG
2
;
Yuan HUANG
2
Author Information
1. Department of Infectious Diseases and Hepatology， Zhuhai People’s Hospital & Zhuhai Hospital Affiliated to Jinan University， Zhuhai， Guangdong 519000， China
2. Department of Hepatology， Beijing Tsinghua Changgung Hospital， School of Clinical Medicine， Tsinghua University， Beijing 102218， China
- Publication Type:Review
- Keywords:
Hepatitis E Virus;
Pregnant Women;
Pregnancy Complications;
Liver Failure
- From:
Journal of Clinical Hepatology
2023;39(10):2448-2453
- CountryChina
- Language:Chinese
-
Abstract:
Previous studies have shown that hepatitis E virus （HEV） infection in pregnancy can cause liver failure and adverse pregnancy outcomes such as miscarriage， stillbirth， and vertical transmission， especially in countries where HEV genotypes 1 and 2 are prevalent. In recent years， HEV infection in China is sporadic and is mainly caused by HEV genotype 4， and although studies have shown that most pregnant women with HEV infection in China have no signfinicant clinical symptoms， there is still a high incidence rate of adverse pregnancy outcomes. This article reviews the recent studies on HEV infection in pregnancy， including the advances in pathogenesis， epidemiology， prognosis， mechanism of severe exacerbation， treatment， and prognosis， and puts forward recommendations for the screening and evaluation of HEV infection in pregnancy.
