Role of heat shock protein 90 in hepatitis B virus replication
10.3969/j.issn.1001-5256.2023.10.023
- VernacularTitle:热休克蛋白90在HBV复制中的作用
- Author:
Yin HUA
1
;
Haili FANG
2
;
Shousheng LIU
3
;
Yongning XIN
1
;
Mei ZHANG
1
;
Shiying XUAN
1
Author Information
1. Department of Infectious Diseases，Qingdao Clinical Medical College Affiliated to Nanjing Medical University，Qingdao Municipal Hospital， Shandong 266011， China
2. Department of Infectious Diseases， Qingdao Eighth People’s Hospital， Qingdao， Shandong 266000， China
3. Clinical Research Center，Qingdao Clinical Medical College Affiliated to Nanjing Medical University，Qingdao Municipal Hospital, Shandong 266011， China
- Publication Type:Review
- Keywords:
Hepatitis B Virus;
HSP90 Heat－Shock Proteins;
Virus Replication
- From:
Journal of Clinical Hepatology
2023;39(10):2443-2447
- CountryChina
- Language:Chinese
-
Abstract:
Hepatitis B virus （HBV） has the characteristics of wide transmission， a high chronic infection rate， and a low cure rate， and improving the cure rate of HBV may help to improve the long－term prognosis of patients. Heat shock protein 90 （Hsp90） is a chaperone protein widely present in organisms. In recent years， more and more studies have shown that Hsp90 is associated with HBV infection and plays an important role in HBV replication. It can not only interact with specific proteins of the virus to promote its replication， but also interact with the host’s own proteins to perform its function. This article reviews the role of Hsp90 in HBV replication in recent studies， so as to provide new theoretical guidance and directions for the development of new anti－HBV drugs targeting Hsp90 and the prevention and treatment of HBV infection in the future.
