Risk factors of stroke-associated pneumonia for patients with mild to moderate acute ischemic stroke
10.3969/j.issn.1006-9771.2023.06.012
- VernacularTitle:轻中度急性缺血性脑卒中并发卒中相关性肺炎的危险因素分析
- Author:
Ting DENG
1
;
Jingmian CHEN
1
;
Xiaomeng LIU
1
;
Xiaohua YAO
1
;
Lushan LIU
1
;
Wei HE
1
;
Tong ZHANG
2
;
Haitao LU
2
Author Information
1. Department of Emergency, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
2. Department of Neurology, Beijing Bo'ai Hospital, China Rehabilitation Research Center, Beijing 100068, China
- Publication Type:Journal Article
- Keywords:
acute ischemic stroke;
stroke-associated pneumonia;
risk factors
- From:
Chinese Journal of Rehabilitation Theory and Practice
2023;29(6):708-713
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the risk factors of stroke-associated pneumonia (SAP) for patients with mild to moderate acute ischemic stroke (AIS). MethodsFrom October, 2016 to December, 2019, 321 patients with mild to moderate AIS in Beijing Bo'ai Hospital were collected and divided into SAP group (n = 71) and non-SAP group (n = 250) according to whether they were complicated with SAP. Gender, age, time from symptom onset to admission, systolic pressure, diastolic pressure, scores of National Institutes of Health Stroke Scale (NIHSS) at admission, and medical history were recorded. Laboratory indexes including the count of white blood cell and platelet, levels of D-dimer, hypersensitive C-reactive protein (hs-CRP) and α-hydroxybutyrate dehydrogenase (α-HBDH) were measured. ResultsUnivariate analysis showed that age, NIHSS score, history of hypertension, atrial fibrillation, prior cerebral infarction, the count of white blood cell and platelet, the levels of D-dimer, hs-CRP and α-HBDH were the influencing factors of SAP (P < 0.2). Multivariate Logistic regression showed that age > 70 years old (OR = 7.121, 95%CI 3.493 to 14.514, P < 0.001), NIHSS score > 4 (5 to 10, OR = 4.861, 95% CI 2.412 to 9.797, P < 0.001), the count of platelet > 300×109/L (OR = 6.978, 95% CI 1.864 to 26.128, P = 0.004), and the level of D-dimer > 1.0 mg/L (OR = 3.036, 95% CI, 1.518 to 6.071, P = 0.002) were the risk factors of SAP. The model fitted the original data well (HL = 1.509，P = 0.680) and appeared a good prediction (AUC = 0.847, 95% CI 0.796 to 0.898, P < 0.001). ConclusionAge > 70 years old, NIHSS score > 4 (5 to 10), the count of platelet > 300×109/L and the level of D-dimer > 1.0 mg/L were the risk factors of SAP for patients with mild to moderate AIS.
