Effect of intermittent theta burst transcranial magnetic stimulation on non-fluent aphasia after stroke
10.3969/j.issn.1006-9771.2023.07.014
- VernacularTitle:间歇性Theta节律经颅磁刺激对脑卒中后非流利性失语的影响
- Author:
Xiaocui JIANG
1
;
Zhen LIU
1
;
Qinglun SU
1
;
Qin ZHAO
1
;
Xiaomei XIA
1
;
Fei LU
1
Author Information
1. The First Affiliated Hospital of Kangda College of Nanjing Medical University/The First People's Hospital of Lianyungang, Lianyungang, Jiangsu 222000, China
- Publication Type:Journal Article
- Keywords:
stroke;
non-fluent aphasia;
transcranial magnetic stimulation;
intermittent theta burst stimulation;
speech
- From:
Chinese Journal of Rehabilitation Theory and Practice
2023;29(7):839-843
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore the therapeutic effect and mechanism of intermittent theta burst transcranial magnetic stimulation (iTBS) on non-fluent aphasia after stroke. MethodsFrom August, 2021 to August, 2022, 50 patients with non-fluent aphasia after stroke in the First People's Hospital of Lianyungang were randomly divided into sham stimulation group (n = 25) and iTBS group (n = 25). Both groups accepted speach training. iTBS group accepted iTBS, and the sham stimulation group received sham iTBS, for four weeks. The serum brain-derived neurotrophic factor (BDNF) was measured, and they were assessed by China Rehabilitation Research Center Standard Aphasia Examination (CRRCAE) and Boston Diagnostic Aphasia Examination before and after treatment. ResultsTwo cases in the sham stimulation group and three cases in iTBS group dropped down. The BDNF level, and listen and understand, repeat, name, read aloud, and total score of CRRCAE improved in two groups after treatment (|t| > 5.012, P < 0.001); and they were better in iTBS group than in the sham stimulation group (|t| > 3.968, P < 0.001). The total effective rate was more in iTBS group than in the sham stimulation group (χ2 = 8.835, P < 0.05). ConclusioniTBS can improve speech function in patients with non-fluent aphasia after stroke, which may associate with the promotion of BDNF.
