Effect of transcranial direct current stimulation combined with task-oriented rehabilitation training on forelimb motor dysfunction in rats with spinal cord injury
10.3969/j.issn.1006-9771.2023.07.006
- VernacularTitle:经颅直流电刺激联合任务导向性康复训练对脊髓损伤大鼠前肢运动障碍的效果
- Author:
Fang LI
1
;
Su HUO
1
;
Jubao DU
1
;
Xiuzhen LIU
1
;
Xiaoshuang LI
2
;
Weiqun SONG
1
Author Information
1. Department of Rehabilitation Medicine, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
2. Department of Rehabilitation Medicine, Beijing University of Chinese Medicine Third Affiliated Hospital (Miyun District), Beijing 101599, China
- Publication Type:Journal Article
- Keywords:
spinal cord injury;
transcranial direct current stimulation;
task-oriented rehabilitation training;
motor function;
rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2023;29(7):777-781
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effect of transcranial direct current stimulation (tDCS) combined with task-oriented rehabilitation training single pellet reaching and grasping (SPG) on the motor function of forelimb in rats with unilateral contusion of C5 spinal cord. MethodsA total of 60 adult male Sprague-Dawley rats were randomly divided into sham operation group (sham group), spinal cord injury (SCI) group, tDCS group, SPG group, false group and tDCS+SPG group, with ten rats in each group. Only C5 lamina was removed in the sham group, and the C5 spinal cord contusion model was established by IH spinal cord impactor in the other five groups. The rats received tDCS in tDCS group, SPG in SPG group, tDCS without current in false group, tDCS combined with SPG in tDCS+SPG group, and no treatment in the SCI and the sham groups. The rats were evaluated with Rearing and Grooming tests, and motor-evoked potential (MEP). ResultsFour weeks after operation, compared with SCI group, the scores of Rearing and Grooming increased in tDCS group and tDCS+SPG group (P < 0.05), and they were more in the tDCS+SPG group than in tDCS group and SPG group (P < 0.05); the score of Grooming increased in SPG group (P < 0.05); while the amplitude of MEP increased in tDCS group, SPG group and tDCS+SPG group (P < 0.05), and the latency shortened in tDCS group and tDCS+SPG group (P < 0.05); and the amplitude increased more in tDCS+SPG group than in tDCS group and SPG group (P < 0.01). ConclusiontDCS could promote the recovery of motor function in rats with SCI, and the combination therapy of tDCS and task-oriented rehabilitation training is more effective.
