Association of serum adiponectin and high sensitivity C-reactive protein levels to short-term outcome in patients with acute ischemic stroke
10.3969/j.issn.1006-9771.2023.10.015
- VernacularTitle:血清脂联素、超敏C-反应蛋白与急性缺血性脑卒中短期预后的相关性
- Author:
Chunlong ZHANG
1
;
Fuliang LIU
2
;
Na SHANG
1
;
Fang LI
1
;
Huizhen LIU
1
Author Information
1. Capital Medical University School of Rehabilitation Medicine, Beijing 100068, China
2. Department of Emergency Medicine, Shandong Juxian People's Hospital, Rizhao, Shandong 276500, China
- Publication Type:Journal Article
- Keywords:
acute ischemic stroke;
adiponectin;
high sensitivity C-reactive protein;
short-term outcome;
association
- From:
Chinese Journal of Rehabilitation Theory and Practice
2023;29(10):1221-1226
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo study the association of serum adiponectin and high sensitivity C-reactive protein (hs-CRP) levels to short-term outcome in patients with acute ischemic stroke (AIS). MethodsClinical data of 216 patients with AIS in Beijing Bo'ai Hospital from January, 2019 to September, 2020 were collected. The serum biochemical indicator was measured in all the patients within 24 hours after enrollment, and adiponectin was detected with enzyme-linked immunosorbent assay. Meanwhile, all patients were evaluated with National Institute of Health Stroke Scale (NIHSS). Modified Rankin Scale (mRS) was used to assess the functional outcome 90 days after onset during follow-up. ResultsThe incidence of poor outcome in patients with AIS within 90 days was 48.1%. Compared with the good outcome group, the serum adiponectin was lower (t = 5.861, P < 0.001) and the serum hs-CRP level was higher (Z = 5.525, P < 0.001) poor outcome group. Reduced serum adiponectin (OR = 0.862, 95%CI 0.751 to 0.975, P < 0.001) and increased serum hs-CRP (OR = 1.215, 95%CI 1.015 to 1.455, P < 0.001) were independent risk factors for poor outcome in patients with AIS. The areas under curve (95% CI) of serum adiponectin and hs-CRP for predicting the outcome of patients with AIS were 0.819 (0.761 to 0.877) and 0.722 (0.654 to 0.791), respectively (P < 0.001). The predictive power of serum adiponectin was higher than that of hs-CRP (Z = 2.151, P = 0.032). The optimum cut-off point of adiponectin was < 3.5 mg/L, and the Yoden index was 0.609, yielding a sensitivity of 0.704 and a specificity of 0.905. ConclusionSerum adiponectin and hs-CRP can serve as independent predictors for short functional outcome in patients with AIS.
