Establishment of rat model of dysphagia after stroke by thread embolism
10.3969/j.issn.1006-9771.2023.10.005
- VernacularTitle:线栓法建立卒中后吞咽障碍的大鼠模型
- Author:
Zhilin HUANG
1
;
Fashao XU
2
;
Jing SHI
2
;
Gan HUANG
1
;
Meifang LIU
2
;
Xiahui ZHANG
2
Author Information
1. Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan 650500, China
2. The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine/Yunnan Provincial Hospital of Traditional Chinese Medicine, Kunming, Yunnan 650021, China
- Publication Type:Journal Article
- Keywords:
stroke;
dysphagia;
animal model;
rats
- From:
Chinese Journal of Rehabilitation Theory and Practice
2023;29(10):1147-1153
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo explore a feasible animal model of dysphagia after stroke. MethodsTwenty-two clean Sprague-Dawley rats were randomly divided into normal group (n = 11) and model group (n = 11). The model of dysphagia after stroke was established by the thread embolism, and the normal group received no intervention. The latency of the first swallowing attack and the number of swallowing were recorded three and seven days after modeling. The cerebral infarction was detected by TTC staining, and the neuronal apoptosis in ischemic brain was detected by TUNEL fluorescence staining. ResultsCompared with the normal group, the swallowing latency prolonged and the number of swallowing reduced three days in the model group, however, there was no significant difference (P > 0.05); seven days after modeling, the swallowing latency prolonged (P < 0.05), and the number of swallowing slightly reduced with little significant difference (P > 0.05). Compared with the normal group, the brain tissue showed obvious infarction area and a large number of apoptotic cells, while the body mass reduced in the model group (P < 0.05). ConclusionThe model rats express some features of dysphagia, which may become a transformation model of dysphagia after stroke.
