Determination of 9 halogenated alkanes in toothpaste by GC⁃MS
10.19428/j.cnki.sjpm.2023.22959
- VernacularTitle:气质联用测定牙膏中9种卤代烷烃类化合物方法的建立
- Author:
Qian PENG
1
;
Xi LIN
1
;
Linying WU
1
;
Dongliang XUAN
1
Author Information
1. Jiading District Center for Disease Control and Prevention，Shanghai 201800，China
- Publication Type:Journal Article
- Keywords:
halogenated alkane;
toothpaste;
GC-MS;
determination
- From:
Shanghai Journal of Preventive Medicine
2023;35(9):905-909
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo establish a GC-MS method for the detection of 9 halogenated alkanes in toothpastes. MethodsVarious brands of toothpastes on the market were collected as the samples. Methanol was used as the extraction solution. After shaking， vortex and centrifugation， the supernatant was filtered by 0.45 μm microporous filter membrane. The content of 9 halogenated alkanes including chloromethane， dichloromethane， chloroform， 1，1，1-trichloroethane， carbon tetrachloride， 1，2-dichloroethane， 1，1，2-trichloroethane， 1，2-dibromoethane， 1，2，3-trichloropropane in the filtrate were determined by GC-MS. ResultsThe 9 halogenated alkanes showed a good linear relationship in the concentration range of 0.03‒1.00 μg·mL-1. The correlation coefficient was ≥0.998 7 with the detection limits of 0.015‒0.056 mg·kg-1. The spiked recoveries were 83.2%‒108.9% with the RSD of 2.0%‒9.8%. In the actual sample analysis， 1，1，2-trichloroethane and 1，2，3-trichloropropane were respectively detected in 6 toothpaste samples from 5 brands. ConclusionThe method is simple， sensitive， accurate， and has good spiked recoveries. It can be used for the determination of halogenated alkanes in toothpastes.
