Application of Natural Ingredients of Traditional Chinese Medicine in Pain Management： A Review
10.13422/j.cnki.syfjx.20231103
- VernacularTitle:中药天然产物在疼痛管理中应用的研究进展
- Author:
Mingze TANG
1
;
Zhen SHEN
1
;
Tianle GAO
1
;
Yanxing HAN
1
;
Jiandong JIANG
1
Author Information
1. State Key Laboratory of Bioactive Substances and Function of Natural Medicine，Institute of Materia Medica， Chinese Academy of Medical Sciences and Peking Union Medical College，Beijing 100050，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
pain;
analgesic;
Chinese herbal compound;
natural ingredients
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(24):260-272
- CountryChina
- Language:Chinese
-
Abstract:
Pain is one of the most prevalent health problems. Current medications for pain are mainly anticonvulsants， tricyclic antidepressants， and opioidergic drugs. However， their therapeutic effectiveness is limited during application， and some even have severe side effects. In recent years， research on natural ingredients from Chinese herbal medicine has been extensively conducted for their analgesic activities. A series of natural ingredients represented by alkaloids， coumarins， flavonoids， and terpenoids have shown great analgesic activity， and further studies on their analgesic mechanism have found that most natural products have multi-target analgesic mechanisms. It can exert analgesic effects by blocking ion channels， regulating related receptors， or inducing anti-inflammatory or antioxidant effects. In addition， many traditional Chinese medicine （TCM） formulas have shown great analgesic ability after clinical application and have multiple complex analgesic mechanisms. The drug cloud （dCloud） theory can better describe the mechanisms， and it can represent the complete therapeutic spectrum of multi-target analgesics from two dimensions， namely the "direct efficacy" that directly inhibits pain signals and the "background efficacy" that targets the root causes of pain. The authors summarized the research progress of natural ingredients with analgesic effects found in Chinese herbal medicine so far， as well as the analgesic efficacy and potential mechanisms of TCM formulas with great analgesic effects in clinical applications， so as to provide a new basis for searching for new analgesic drugs from TCM.
