Syndrome Differentiation-based Treatment of Diarrhea-predominant Irritable Bowel Syndrome with Chinese Medicine via 5-HT Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20232291
- VernacularTitle:基于5-羟色胺信号通路探讨中医药辨证治疗腹泻型肠易激综合征的研究进展
- Author:
Qingrui YANG
1
;
Zeyu HU
1
;
Yuyu LEI
1
;
Xinzhu LI
1
;
Huan CHEN
1
;
Wei CUI
1
;
Haitao LIU
2
;
Xiaoquan DU
2
Author Information
1. Shaanxi University of Chinese Medicine，Xianyang 712046，China
2. The Affiliated Hospital of Shaanxi University of Chinese Medicine，Xianyang 712000，China
- Publication Type:Journal Article
- Keywords:
diarrhea-predominant irritable bowel syndrome;
5-hydroxytryptamine;
serotonin;
traditional Chinese medicine;
traditional Chinese medicine syndrome
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(24):250-259
- CountryChina
- Language:Chinese
-
Abstract:
Diarrhea-predominant irritable bowel syndrome （IBS-D） is a chronic functional bowel disorder characterized by abdominal pain and diarrhea， with visceral hypersensitivity and abnormal gastrointestinal dynamics as the pathophysiological basis. The brain-gut interaction plays a role in pain-related functional gastrointestinal disorders， especially IBS-D. 5-Hydroxytryptamine （5-HT）， as an important brain-gut peptide regulating gastrointestinal function， affects brain activity， gastrointestinal motility， pain perception， mucosal inflammation， and immune response through brain-gut interaction and is associated with the occurrence and development of IBS-D. In recent years， traditional Chinese medicine （TCM） has shown great potential to mitigate gastrointestinal symptoms and improve the quality of life with its holistic view and treatment based on syndrome differentiation. Studies have shown that TCM treats IBS-D by regulating the 5-HT signaling pathway. With a focus on syndrome differentiation in TCM， this paper systematically describes the efficacy and mechanism of TCM in treating different TCM syndromes of IBS-D via the 5-HT signaling pathway， aiming to provide a scientific basis for TCM treatment of this disease.
