Mechanism of Eucommiae Cortex and Its Active Components in Treatment of Knee Osteoarthritis： A Review
10.13422/j.cnki.syfjx.20231213
- VernacularTitle:杜仲及其有效成分治疗膝骨关节炎的作用机制研究现状
- Author:
Qu ZHENG
1
;
Yu ZHANG
1
;
Yongju YANG
2
;
Heshan YU
2
;
Xuefeng GUAN
3
;
Yu CHEN
4
Author Information
1. Liaoning University of Traditional Chinese Medicine（TCM）， Shenyang 110847， China
2. Affiliated Hospital of Liaoning University of TCM， Shenyang 110847，China
3. Shenyang Pharmaceutical University， Shenyang 110016， China
4. The Second Affiliated Hospital of Liaoning University of TCM， Shenyang 110034， China
- Publication Type:Journal Article
- Keywords:
Eucommiae Cortex;
active ingredients;
knee osteoarthritis;
mechanism of action;
signaling pathways
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(24):225-232
- CountryChina
- Language:Chinese
-
Abstract:
Knee osteoarthritis （KOA） is a common degenerative joint disease in the middle-aged and elderly. The incidence of KOA is rising as the population aging aggravates and the obese population grows. KOA seriously affects the health and daily life of the patients. The commonly used drugs for the symptomatic treatment of KOA include non-steroidal anti-inflammatory drugs， cartilage protective drugs， and opioid analgesics， which have limited therapeutic effects and induce obvious adverse drug reactions. Eucommiae Cortex is one of the commonly used Chinese herbal medicines for the treatment of KOA， while its pharmacological material basis and mechanism remain unclear， which limits its clinical application. The active ingredients of Eucommiae Cortex for treating KOA mainly include iridoids （geniposide， aucubin）， lignans （pinoresinol diglucoside）， flavonoids （quercetin， astragaloside， baicalein， hyperoside， and kaempferol）， phenylpropanoids （chlorogenic acid）， and polysaccharides. These compounds regulate the levels of inflammatory cytokines， inhibit oxidative stress， protect chondrocytes， balance the synthesis and degradation of extracellular matrix， and control the progression of KOA via the mitogen-activated protein kinase， nuclear factor-κB， phosphatidylinositol-3-kinase/protein kinase B， and Janus kinase 1/signal transducer and activator of transcription 3 signaling pathways. This paper introduces the mechanisms of Eucommiae Cortex and its active components in the treatment of KOA， aiming to provide a theoretical basis for the development of new drugs for KOA.
