Chinese Medicine Polysaccharides Induce Apoptosis of Gastric Cancer Cells： A Review
10.13422/j.cnki.syfjx.20230326
- VernacularTitle:中药多糖类成分诱导胃癌细胞凋亡的研究进展
- Author:
Jinxin WANG
1
;
Liqun LI
2
;
Maoguang HUANG
1
;
Feng LUO
1
;
Yueying CHEN
1
;
Junling ZHANG
1
;
Yiyi HE
1
;
Shengnan CAI
1
;
Sheng XIE
2
Author Information
1. Graduate School， Guangxi University of Chinese Medicine，Nanning 530001， China
2. The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530001， China
- Publication Type:Journal Article
- Keywords:
gastric cancer（GC）;
Chinese medicine polysaccharides;
apoptosis;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(24):202-209
- CountryChina
- Language:Chinese
-
Abstract:
Gastric cancer （GC） is a digestive tract tumor that occurs in the epithelial tissues of the gastric mucosa， seriously affecting the life and health of patients， and its mortality rate ranks the third among malignancies. Although medical technology has made great progress in recent years， the progression of GC still cannot be effectively controlled by surgery， chemotherapy， and targeted therapy. The pathogenesis of GC is extremely complex and is closely related to the tumor microenvironment， chronic inflammation， and immune escape， among which the reduction of tumor cell apoptosis is one of the important mechanisms for the occurrence and development of GC. Apoptosis refers to the process of spontaneous termination of cell life caused by genes under specific physiological or pathological conditions， which is of great significance for maintaining the stability of the internal environment. Researchers have found that in the GC state， mitochondrial endogenous apoptosis， endoplasmic reticulum stress， external death receptors， and other apoptosis pathways are regulated by multiple signaling pathways and genes， which together lead to the decline of GC cell apoptosis rate and thus promote the progression of GC. Chinese medicine is advantageous and characterized by multiple components， multiple targets， synergistic effect， and few adverse reactions. A large number of studies have shown that polysaccharide components， as effective components of Chinese medicine， have biological activities such as cancer inhibition， blood sugar control， anti-inflammation， antioxidant damage， and anti-virus， and can effectively inhibit the deterioration of GC by inducing cell apoptosis， gradually becoming a hot spot in GC drug research and development. However， systematic reviews on the apoptosis of GC induced by Chinese medicine polysaccharides are rarely reported. Therefore， this paper analyzed and summarized the studies of Chinese medicine polysaccharides in promoting apoptosis and interfering with GC， in order to provide a theoretical basis for the basic research， new drug development， and clinical application of Chinese medicine polysaccharides in the intervention of GC.
