Intervention of Lung Cancer by Chinese Medicine and Active Components via Affecting Gut Microbiota：A Review
10.13422/j.cnki.syfjx.20230826
- VernacularTitle:中药及活性成分影响肠道菌群干预肺癌治疗的研究进展
- Author:
Yu LIAO
1
;
Yanping WEN
1
;
Lingshuang LIU
1
Author Information
1. Longhua Hospital，Shanghai University of Traditional Chinese Medicine， Shanghai 200032， China
- Publication Type:Journal Article
- Keywords:
lung cancer;
gut microbiota;
gut-lung axis;
Chinese medicine;
active components
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(24):194-201
- CountryChina
- Language:Chinese
-
Abstract:
As a malignancy with the highest morbidity and mortality in the world， lung cancer poses a huge threat to the health and life safety of all human beings. Most lung cancer patients are already in the advanced stage when they are diagnosed， and the treatment of advanced lung cancer often brings heavy mental pressure and economic burden to patients but has little effect. Therefore， the early diagnosis and treatment of lung cancer has become a major problem for medical researchers. At present， chemotherapy， immunotherapy， targeted therapy， and other treatment methods still have problems such as intolerance of patients and drug resistance， so there is an urgent need for human beings to seek new methods to treat lung cancer. Currently， the relationship between gut microbiota and disease occurrence， development， and prognosis， and the treatment of diseases by regulating gut microbiota have become a hot field of medical research. There are significant differences in gut microbiota between lung cancer patients and healthy people. Intestinal microorganisms can act on the respiratory system through the gut-lung axis， thereby affecting the occurrence， development， and prognosis of lung cancer and other respiratory diseases. As a peculiar means of treatment in China， Chinese medicine can effectively delay tumor progression， prevent postoperative recurrence and metastasis， reduce complications in the course of treatment， improve the quality of life， and prolong the survival of patients. Therefore， Chinese medicine is widely involved in the treatment of malignancies. Some Chinese medicine monomers， compounds， and active components have been found to regulate the gut microbiota. They can regulate the metabolism of the body， control the inflammatory response， build an immune barrier， or play a synergistic effect with various lung cancer treatments by affecting gut microbiota， so as to achieve the anti-tumor purpose. This article systematically reviewed the research on Chinese medicine and effective components in regulating gut microbiota， creating tumor-suppressing microenvironment， and intervening in the treatment of lung cancer， in order to provide new research ideas for the treatment of lung cancer.
