Application of Self-assembled Nano-strategies of Traditional Chinese Medicine in Tumor Therapy： A Review
10.13422/j.cnki.syfjx.20230763
- VernacularTitle:中药自组装纳米策略在肿瘤治疗中应用的研究进展
- Author:
Ju HUANG
1
;
Yu ZHU
1
;
Hang XIAO
2
;
Songtao LI
1
;
Jingwen LIU
1
;
Qiao ZHENG
1
;
Xiangrui MENG
1
;
Jianyuan TANG
1
Author Information
1. Hospital of Chengdu University of Traditional Chinese Medicine（TCM），Chengdu 610032，China
2. School of TCM，Capital Medical University，Beijing 100069，China
- Publication Type:Review
- Keywords:
traditional Chinese medicine（TCM）;
self-assembly nanoparticles;
antitumor;
combined chemotherapy;
stability;
decoction;
active ingredients
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2023;29(24):185-193
- CountryChina
- Language:Chinese
-
Abstract:
Chinese medicine self-assembly nano-strategies（CSAN） is to utilize the self-assembly property of Chinese medicine components， so that the Chinese medicine components can self-assemble to form structurally stable nano-preparations through non-covalent interactions. The formation of Chinese medicine self-assembly nano-preparations is often a synergistic result of a variety of non-covalent interactions， and many Chinese medicine monomers are susceptible to self-assembly due to their structural characteristics， and the phenomenon of self-assembly of Chinese medicine is also common in the decoction of single or compound Chinese medicine， which has attracted the attention of researchers. It is found that CSAN can improve the solubility and bioavailability of active components in Chinese medicine， which is of positive significance for the development and application of insoluble components of Chinese medicine. The self-assembly phenomenon of Chinese medicine decoction is closely related to the therapeutic efficacy， and the study of self-assembly phenomenon of Chinese medicine will bring a new perspective for the explanation of the mechanism of Chinese medicine decoction. At the same time， traditional Chinese medicine（TCM） has unique advantages in the field of anti-tumor. The application of CSAN in the field of oncology can not only exert the anti-tumor effect of the active components of Chinese medicine directly， but also act as a natural nano-carrier to carry chemotherapy drugs for combination chemotherapy， improve the targeting of drugs， enhance the anti-tumor efficacy， and reduce the side effects of chemotherapy， which has excellent anti-tumor potential. The preparation method of Chinese medicine self-assembly nano-preparations is simple， low cost， and has better safety than traditional nano-preparations， which is conducive to the promotion of the clinical transformation of nano-preparations， and also helps to provide new strategies and perspectives for promoting the modernization of TCM. Therefore， based on a large number of researches in this field in recent years， this paper reviewed the formation mechanism， different assembly forms， formation conditions and stability of Chinese medicine self-assembly nano-preparations by searching databases such as China national knowledge infrastructure（CNKI）， PubMed， WanFang data and VIP， and summarized the application of CSAN in different tumor therapies， providing a reference for further research on CSAN.
