Reviewing the Compounding Risks for Tuberculosis DrugInduced Liver Injury in a Patient with Transfusion Dependent  Thalassaemia

Author: Nursafinas Rofii ^{1
,

2} ; Ummi Nadira Daut ^{1
,

3} ; Su Yin Lau ^{1
,

2}
Author Information

1. Department of Medicine, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 Serdang, Selangor, Malaysia&
2. Gastroenterology and Hepatology Unit, Hospital Pengajar University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
3. Respiratory Unit, Hospital Pengajar University Putra Malaysia, 43400 Serdang, Selangor, Malaysia
Publication Type:Case Reports
Keywords: Antitubercular agents, Case report, Drug-induced liver injury, Tuberculosis, Thalassaemia major
From:Malaysian Journal of Medicine and Health Sciences 2023;19(No.4):365-367
CountryMalaysia
Language:English
Abstract: A patient presents with jaundice three weeks into commencement of anti-tuberculosis therapy (ATT). Tuberculosis drug-induced liver injury (TB-DILI) is a main concern in patients commencing ATT. Studies have reported various risk factors associated with TB-DILI, urging vigilance in monitoring liver enzymes in these patients. We aim to review the causes of jaundice in a patient with transfusion dependent thalassaemia commenced on ATT and highlight the risk factors associated with TB-DILI.
Full text:11.2023my1602.pdf