The Role of Oxidative Stress and Inflammation in Prediabetes: A Review
https://doi.org/10.47836/mjmhs.19.4.45
- Author:
Fatma S.A Saghir
1
;
Farrah Shafeera Ibrahim
1
;
Zulkhairi Amom
1
;
Lekhsan Othman
2
Author Information
1. Department of Basic Sciences, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Puncak Alam, Selangor, Malaysia
2. Jeffrey Cheah School of Medicine, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, 47500 Subang Jaya, Selangor
- Publication Type:Review
- Keywords:
Prediabetes, Hyperglycaemia, Oxidative stress, Antioxidant, Inflammation
- From:Malaysian Journal of Medicine and Health Sciences
2023;19(No.4):326-331
- CountryMalaysia
- Language:English
-
Abstract:
Prediabetes is a condition in which blood glucose level is above the normal but below the diagnostic value of
diabetes mellitus. Hyperglycaemia can upregulate markers of chronic inflammation and contribute to the overproduction of reactive oxygen species (ROS), which ultimately causes increased oxidative stress. This leads to beta-cell
dysfunction and insulin resistance, which are involved in the pathogenesis of prediabetes status. Proper treatment
of hyperglycaemia, inhibition of ROS overproduction, and suppression of inflammation are crucial for delaying the
onset of diabetes. Therefore, it is essential to determine and understand the mechanisms involved in prediabetes.
This review discusses the relationship between oxidative stress and prediabetes, along with the inflammation’s role
in prediabetes. Additionally, the effects of some biomarkers of oxidative stress in prediabetes, inflammatory markers,
and their influence on chronic inflammation are also briefly reviewed. Finally, the role of antioxidant and anti-inflammatory markers are discussed.
- Full text:11.2023my1596.pdf
