Effect of Moringa oleifera Leaf Extracts on Depression in Rheumatoid Arthritis Patients
https://doi.org/10.47836/mjmhs.19.4.25
- Author:
Afifah Syifaul Ummah
1
;
Faizal Muhammad
2
;
Yulie Erida Nur Rahmawati
3
;
Isa Ridwan
4
;
Arief Nurudhin
1
;
Eillien Ramadhani Fauzi
1
;
Ratih Tri Kusuma Dewi
1
;
Yulyani Werdiningsih
1
Author Information
1. Internal Medicine Department, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia 57126
2. Neurology Department, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia 57126
3. Balai Besar Kesehatan Paru Masyarakat Bandung, Ministry of Health of the Republic of Indonesia, Bandung, Indonesia 40241
4. Orthopedics and Traumatology Department, Rumah Sakit Umum Daerah Kota Banjar, Banjar, Indonesia 40293
- Publication Type:Journal Article
- Keywords:
Depression, Stress, Rheumatoid arthritis, Moringa oleifera, Adjuvant therapy
- From:Malaysian Journal of Medicine and Health Sciences
2023;19(No.4):166-170
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: Depression is a mental disorder that is increasingly common nowadays. It can emerge as morbidity
in chronic diseases such as rheumatoid arthritis (RA). The leaf extract of Moringa oleifera (MO) has shown to be a
complementary therapy in depression, besides its anti-inflammatory role. This study aimed to evaluate the effect of
MO leaf extract on Depression in RA patients. Methods: This quasi-experimental study with a pretest-posttest control
group design comprised 32 RA patients. The participants were divided into the control (n = 16) and intervention (n
= 16) groups. The intervention group received two MO leaf extract-containing capsules b.i.d. for 28 days. The depression was evaluated by Beck Depression Inventory (BDI-II) and serum cortisol test. Statistical analyses used both
paired and unpaired t-tests. Results: The posttest means comparison of BDI-II and serum cortisol showed a significant
difference between groups (p = 0.031 and p = 0.015, respectively). The pretest-posttest difference within the control
group did not show significant improvement in BDI-II and serum cortisol (p = 0.076 and p = 0.106). Meanwhile,
significant BDI-II and serum cortisol improvement were found in the intervention group (p = 0.003 and p = 0.048,
respectively). Conclusion: MO leaf extract reduces depression in RA patients based on BDI-II and serum cortisol
assessment.
- Full text:11.2023my1576.pdf
