Efficacy of a single- dose fosfomycin as antibiotic prophylaxis prior to transrectal ultrasound-guided prostate biopsy
- Author:
Claudette C. Calata
1
;
Pedro L. Lantin, III
1
Author Information
- Publication Type:Journal Article
- Keywords: Prophylactic antibiotic; Prostate biopsy; Transrectal Ultrasonography
- MeSH: Fosfomycin; Urinary Tract Infections
- From: Philippine Journal of Urology 2017;27(2):103-109
- CountryPhilippines
- Language:English
-
Abstract:
Objectives:The goal to prevent increasing antibiotic resistance in urologic procedures has a significant impact on the choice of preoperative antibiotic prophylaxis. The efficacy of an old-new antibioticfosfomycin in TRUS-guided prostate biopsy was also evaluated.
Methods:Included were patients who underwent TRUS-guided prostate biopsy from August 1, 2015- July 31, 2016. Patients who satisfied the inclusion criteria were included. Patients were asked to take a single dose of 3g oral fosfomycin 1-3 hours prior to the procedure. Urinalysis was taken pre biopsy and post biopsy (at least 7-10 days). Occurrence of afebrile and febrile UTI were noted. Patients were informed of the signs and symptoms that need to be reported to the investigators.
Results:There were 74 patients enrolled in the study. The mean average age of patients was 66.5(±7). Majority of patients were having moderate lower urinary tract symptoms (40.5%) followed by patients with indwelling foley catheter (31.1%). Seventeen percent of patients had concomitant diseases like diabetes mellitus, cystolithiasis, nephrolithiasis, hypertension, etc. Pre biopsy, 51.4% of patients had asymptomatic urinary tract infection and 35% of these patients showed resolution of UTI post biopsy. The incidence of febrile UTI was 4%, 3.8% of patients with UTI pre biopsy and 50% of patients without UTI pre biopsy. Finally, the presence of afebrile and febrile UTI pre and post biopsy was statistically significant at 5% level of significance.
Conclusion:Single dose oral fosfomycin as prophylactic antibiotic in TRUS- guided prostate biopsy can be an alternative to reduce the rate of fluoroquinolone- resistant infections. - Full text:51-Full Research Text-125-1-10-20200227.pdf
