Bone metabolism and fracture risk in diabetes mellitus

Melisa Puspitasari; Dyah Purnamasari; Bambang Setyohadi; Harry Isbagio

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Bone metabolism and fracture risk in diabetes mellitus

Author: Melisa Puspitasari ¹ ; Dyah Purnamasari ² ; Bambang Setyohadi ³ ; Harry Isbagio ³
Author Information

1. Department of Internal Medicine, Faculty of Medicine University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
2. Division of Metabolism and Endocrinology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
3. Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Publication Type:Journal Article
Keywords: Bone metabolism
MeSH: Diabetes Mellitus; Bone Remodeling; Biomarkers
From: Journal of the ASEAN Federation of Endocrine Societies 2017;32(2):90-99
CountryPhilippines
Language:English
Abstract: Individuals with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) are at increased risk for fragility fractures. Bone mineral density (BMD) is decreased in T1DM but often normal or even elevated in T2DM when compared with age-matched non-DM populations. However, bone turnover is decreased in both T1DM and T2DM. The pathophysiologic mechanisms leading to bone fragility is multifactorial, and potentially leads to reduced bone formation, altered bone microstructure and decreased bone strength. Interestingly, different antidiabetic treatments may influence fracture risk due to effects on glycemic control, triggering of hypoglycemic events or osteoblastogenesis.
Full text:431-Article Text-5010-1-10-20171025.pdf